BAC-CLONING AND MUTAGENESIS OF HERPESVIRUS GENOMES
Cloning as an infectious plasmid and mutagenesis in E.coli has become the method of choice for genetic analysis of viruses with small genomes. Until recently, this approch was not accessible for herpesviruses since their large genomes (150 to 230 kbp) could not be cloned in one piece in E.coli....
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